Beavis and Butt-head watch Twilight at a theater, which gives them the idea to become undead to become appealing to ladies. Later in class, David Van Driessen teaches the students about the undead and after Butt-head asks Van Driessen how to become undead, he tells them that they must be bitten by one, which prompts the duo to leave class and look for a member of the undead. Hoping to become a member of the undead themselves, the duo eventually find a crazy old homeless man they mistake for a werewolf due to having white hair cover his head and much of his face and his large canine teeth. Beavis and Butt-head ask the old man to bite them. The man asks for a dollar, but Butt-head gives him a piece of gum instead, and he bites them numerous times. It turns out that the old fellow has Hepatitis C, infecting both Beavis and Butt-head with it after he bites them. The duo are later seen at home, feeling decidedly poorly, their pallid skin sporting a slew of bite marks and bruises, but think they have become werewolves. While the boys are hanging out in town, two pretty young women find them and discover that they are infected with Hepatitis C and take them to the hospital, even though the duo thought the two beauties were going to take them out on a date. At the hospital, it is discovered that Beavis and Butt-head not only contracted Hepatitis C, but Hepatitis A, Hepatitis B, gonorrhea, gangrene, staph and MRSA as well, surprising the doctor that they are still alive. As the nurse attempts to insert catheters, the two dimwitted teens start giggling at her touching their penises, despite being in a deep coma. With Butt-head uttering the word: "Deep...".
- Mr. Van Driessen
- MGMT – "Kids"
- A clip from Jersey Shore
- Skrillex Skrillex – "First of the Year"
- First episode to air in 2011.
- This was the first Beavis and Butt-head season to use digital ink and paint.
- The episode was originally going to be called Frozen! but changed to Werewolves of Highland.
- The title is a play on the title of the song “Werewolves of London”, by Warren Zevon.
- This episode, along with Crying marks the first time where Beavis and Butthead watch MTV sitcoms.
- This episode marks the first time Beavis said "Fire" without being censored since the 90s. He ends up saying it during the intro to the Kids music video about 5 minutes into the episode.
- The homeless character who bites the duo has a voice almost identical to Spongy, a similar bum character from Mike Judge's other show, King of the Hill.
Season 2: Scientific Stuff · Good Credit · Burger World · Baby Makes Uh, Three · Beware of the Butt · At the Sideshow · Customers Suck · Sick · Home Improvement · Way Down Mexico Way · Way Down Mexico Way Part 2 · At the Movies · No Laughing · No Laughing Part 2 · The Butt-head Experience · Lawn and Garden · Stewart's House · For Better or Verse · Bedpans & Broomsticks · Babes 'R' Us · Yogurt's Cool · Heroes · Sign Here · Washing the Dog · Friday Night · Be All You Can Be
Season 3: Comedians · Carwash · Couch-Fishing · Incognito · Kidnapped · Kidnapped Part 2 · Naked Colony · Tornado · Cleaning House · Scratch 'N' Win · Scared Straight · Eating Contest · Sporting Goods · Sperm Bank · Buff 'N' Stuff · Citizen Butt-head · Citizen Butt-head Part 2 · Politically Correct · Ball Breakers · Meet God · Meet God Part 2 · True Crime · The Trial · The Crush · Plate Frisbee · Canoe · Young, Gifted & Crude · Foreign Exchange · A Very Special Christmas With Beavis and Butt-head · Closing Time · Most Wanted
Season 4: Wall of Youth · Cow Tipping · Trouble Urinating · Rabies Scare · They're Coming To Take Me Away, Huh Huh · Jump! · Pumping Iron · Let's Clean it Up · 1-900-BEAVIS · Water Safety · Blackout! · Late Night with Butt-head · The Final Judgement of Beavis · Pool Toys · Madame Blavatsky · Beavis and Butt-head's Island · Figure Drawing · Date Bait · Butt is it Art? · Right On · Manners Suck · The Pipe of Doom · Safe Driving · Mr. Anderson's Balls · Patients Patients · Teen Talk · Crisis Line · Beavis and Butt-head vs. the Vending Machine · Generation in Crisis · Radio Sweethearts · The Great Cornholio · Liar! Liar!
Season 5: Held Back · Killing Time · Beard Boys · Choke · Safe House · Hard Sell · Walkathon · Temporary Insanity · Dude, a Reward · Walking Erect · Career Day · Plastic Surgin · Take a Number · Beaverly Buttbillies · Tainted Meat · Stewart Moves Away · Top O' The Mountain · Party · Wet Behind the Rears · Bad Dog · Lightning Strikes · Dream On · Candy Sale · Animation Sucks · What's the Deal? · The History of Women · To the Rescue · I Dream of Beavis · Pregnant Pause · Here Comes the Bride's Butt · Screamers · Beavis, Can You Spare a Dime? · Skin Trade · Oil Change · Buttniks · Bang the Drum Slowly, Dumbass · Another Friday Night · Tired · Close Encounters · Womyn · Premature Evacuation · Whiplash · Spare Me · Patsies · Murder Site · Spanish Fly · Sexual Harassment · Bus Trip · Green Thumbs · Steamroller
Season 6: Bungholio: The Lord of the Harvest · The Mystery of Morning Wood · U.S. History · Feel A Cop · Date Watchers · Blood Pressure · Huh-Huh-Humbug · It's a Miserable Life · Babysitting · Vidiots · Stewart Is Missing · Gang Of Two · Sprout · Prank Call · No Service · Yard Sale · P.T.A. · Substitute · Shopping List · Buy Beer
Season 7: Butt, Butt, Hike! · Vaya Con Cornholio · Evolution Sucks · Ding Dong Ditch · Just For Girls · A Very Special Episode · Dumbasses Anonymous · Underwear · Head Lice · Cyber-Butt · Nosebleed · Citizens Arrest · Pierced · A Great Day · On Strike · Follow Me · Nothing Happening · Take A Lap · Shortcuts · Bride of Butt-head · Special Delivery · Woodshop · TV Violence · Canned · Garage Band · Impotence · The Miracle That Is Beavis · Shopping Cart · Inventors · Die Fly, Die! · Drinking Butt-ies · Work Is Death · Breakdown · Graduation Day · The Future of Beavis and Butt-head · Speech Therapy · Leave It to Beavis · Butt Flambé · Our Founding Losers · Beavis and Butt-head Do Thanksgiving · Beavis and Butt-head Are Dead
Season 8: Werewolves of Highland · Crying · Daughter's Hand · Tech Support · Holy Cornholio · Drones · Supersize Me · Bathroom Break · The Rat · Spill · Doomsday · Dumb Design · Copy Machine · Holding · Used Car · Bounty Hunters · Time Machine · Massage · School Test · Snitchers · Whorehouse · Going Down